GLP-1 Weight Loss Medications
FDA-approved GLP-1 receptor agonists are revolutionizing medical weight loss — helping patients lose 15–22% of body weight with once-weekly dosing and ongoing provider support.
Semaglutide
Most PrescribedWegovy® / Ozempic® · GLP-1 Receptor Agonist
How It Works
Mimics the GLP-1 hormone to reduce appetite, slow gastric emptying, and regulate blood sugar — leading to significant, sustained weight loss.
Key Benefits
- FDA-approved for chronic weight management
- Reduces appetite and food cravings
- Improves cardiovascular risk factors
- Available in pill or injection form
- Clinically proven in large-scale trials
Common Side Effects
- Nausea (most common, usually temporary)
- Diarrhea or constipation
- Decreased appetite
- Abdominal discomfort
- Headache
Who Is This For?
Adults with BMI ≥30, or BMI ≥27 with at least one weight-related condition (type 2 diabetes, high blood pressure, high cholesterol).
Ready to start Semaglutide?
Get matched with a licensed provider and receive your prescription in days.
⚕️ GLP-1 medications require a prescription. A licensed provider will determine if treatment is appropriate for you. Medication costs are separate from consultation fees.
Before & After Transformations
Real patients, real results with GLP-1 medications and provider support.
Average Weight Loss Timeline
"I finally feel like myself again. The medication made it possible to break through a plateau I'd been stuck at for years."
"My doctor said my blood work looks better than it has in a decade. The weight loss was life-changing."
* Individual results vary. Images are representative. Average weight loss with GLP-1 medications is 15–22.5% of body weight over 12–18 months when combined with diet and exercise.
Understanding Side Effects
Transparency matters. Here's what to expect and how to manage common side effects.
Nausea
CommonMost common side effect, typically mild and decreases after 4–8 weeks as your body adjusts.
Eat smaller meals, avoid fatty foods, stay hydrated. Take medication with food initially.
Constipation
CommonSlowed gastric emptying can affect bowel regularity, especially in the first few months.
Increase fiber intake gradually, drink 8+ glasses of water daily, consider a stool softener.
Fatigue
ModerateReduced caloric intake may cause temporary tiredness as your body adapts to lower energy levels.
Ensure adequate protein intake (1.6g/kg), maintain sleep hygiene, light exercise helps.
Appetite Changes
ExpectedSignificant reduction in hunger and food cravings is the primary mechanism of action — this is the medication working.
Focus on nutrient-dense foods, eat protein first, don't skip meals even if not hungry.
Muscle Loss Prevention
ImportantWeight loss from any method can include muscle mass. Proactive steps are essential to preserve lean tissue.
Resistance training 2–3x/week, protein intake of 1.6–2.2g/kg body weight, consider creatine supplementation.
Medical Note: Most side effects are mild and temporary, typically resolving within 4–8 weeks. Always report persistent or severe symptoms to your healthcare provider. Dose titration (starting low and increasing gradually) significantly reduces side effect severity.
Top GLP-1 Providers Reviewed
Independent reviews from our editorial team. Click to read the full review.
Ro
From $145/mo
Excellent all-around GLP-1 provider with fast turnaround and competitive pricing.
Hims
From $199/mo
Well-known platform with a smooth user experience and broad treatment options.
Hers
From $199/mo
Tailored specifically for women's weight loss with a supportive, empathetic approach.
Calibrate
From $135/mo
Comprehensive metabolic health program with the highest reported patient satisfaction.
PlushCare
From $0*/mo
Best option if you have insurance — most major plans accepted with low copays.
Ro
From $145/mo
Excellent all-around GLP-1 provider with fast turnaround and competitive pricing.
Hims
From $199/mo
Well-known platform with a smooth user experience and broad treatment options.
Hers
From $199/mo
Tailored specifically for women's weight loss with a supportive, empathetic approach.
Calibrate
From $135/mo
Comprehensive metabolic health program with the highest reported patient satisfaction.
PlushCare
From $0*/mo
Best option if you have insurance — most major plans accepted with low copays.
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